TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment

TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment

Hypoxia and interactions with bone marrow (BM) stromal cells have emerged as essential components of the leukemic BM microenvironment in promoting leukemia cell survival and chemoresistance. High levels of transforming growth factor beta 1 (TGFβ1) produced by BM stromal cells in the BM niche regulat...

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Bibliographic Details
Main Authors: Tabe, Yoko, Shi, Yue Xi, Zeng, Zhihong, Jin, Linhua, Shikami, Masato, Hatanaka, Yasuhito, Miida, Takashi, Hsu, Frank J., Andreeff, Michael, Konopleva, Marina
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695026/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695026/

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