Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids

Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substit...

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Main Authors:	Zhang, Jing, Fu, Xin-Ling, Yang, Nan, Wang, Qiu-An
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690745/

id	pubmed-3690745
recordtype	oai_dc
spelling	pubmed-36907452013-07-09 Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids Zhang, Jing Fu, Xin-Ling Yang, Nan Wang, Qiu-An Research Article Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. Among them, 13 and 17~22 are new compounds. The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds 2, 4, 5, 6, 10, 15, and 19 exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol). Hindawi Publishing Corporation 2013-06-06 /pmc/articles/PMC3690745/ /pubmed/23844408 http://dx.doi.org/10.1155/2013/649485 Text en Copyright © 2013 Jing Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhang, Jing Fu, Xin-Ling Yang, Nan Wang, Qiu-An
spellingShingle	Zhang, Jing Fu, Xin-Ling Yang, Nan Wang, Qiu-An Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
author_facet	Zhang, Jing Fu, Xin-Ling Yang, Nan Wang, Qiu-An
author_sort	Zhang, Jing
title	Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
title_short	Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
title_full	Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
title_fullStr	Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
title_full_unstemmed	Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
title_sort	synthesis and cytotoxicity of chalcones and 5-deoxyflavonoids
description	Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. Among them, 13 and 17~22 are new compounds. The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds 2, 4, 5, 6, 10, 15, and 19 exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol).
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690745/
_version_	1611988905723166720

Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids

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