LAMP: A Database Linking Antimicrobial Peptides

The frequent emergence of drug-resistant bacteria has created an urgent demand for new antimicrobial agents. Traditional methods of novel antibiotic development are almost obsolete. Antimicrobial peptides (AMPs) are now regarded as a potential solution to revive the traditional methods of antibiotic...

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Main Authors:	Zhao, Xiaowei, Wu, Hongyu, Lu, Hairong, Li, Guodong, Huang, Qingshan
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688957/

id	pubmed-3688957
recordtype	oai_dc
spelling	pubmed-36889572013-07-02 LAMP: A Database Linking Antimicrobial Peptides Zhao, Xiaowei Wu, Hongyu Lu, Hairong Li, Guodong Huang, Qingshan Research Article The frequent emergence of drug-resistant bacteria has created an urgent demand for new antimicrobial agents. Traditional methods of novel antibiotic development are almost obsolete. Antimicrobial peptides (AMPs) are now regarded as a potential solution to revive the traditional methods of antibiotic development, although, until now, many AMPs have failed in clinical trials. A comprehensive database of AMPs with information about their antimicrobial activity and cytotoxicity will help promote the process of finding novel AMPs with improved antimicrobial activity and reduced cytotoxicity and eventually accelerate the speed of translating the discovery of new AMPs into clinical or preclinical trials. LAMP, a database linking AMPs, serves as a tool to aid the discovery and design of AMPs as new antimicrobial agents. The current version of LAMP has 5,547 entries, comprising 3,904 natural AMPs and 1,643 synthetic peptides. The database can be queried using either simply keywords or combinatorial conditions searches. Equipped with the detailed antimicrobial activity and cytotoxicity data, the cross-linking and top similar AMPs functions implemented in LAMP will help enhance our current understanding of AMPs and this may speed up the development of new AMPs for medical applications. LAMP is freely available at: http://biotechlab.fudan.edu.cn/database/lamp. Public Library of Science 2013-06-18 /pmc/articles/PMC3688957/ /pubmed/23825543 http://dx.doi.org/10.1371/journal.pone.0066557 Text en © 2013 Zhao et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhao, Xiaowei Wu, Hongyu Lu, Hairong Li, Guodong Huang, Qingshan
spellingShingle	Zhao, Xiaowei Wu, Hongyu Lu, Hairong Li, Guodong Huang, Qingshan LAMP: A Database Linking Antimicrobial Peptides
author_facet	Zhao, Xiaowei Wu, Hongyu Lu, Hairong Li, Guodong Huang, Qingshan
author_sort	Zhao, Xiaowei
title	LAMP: A Database Linking Antimicrobial Peptides
title_short	LAMP: A Database Linking Antimicrobial Peptides
title_full	LAMP: A Database Linking Antimicrobial Peptides
title_fullStr	LAMP: A Database Linking Antimicrobial Peptides
title_full_unstemmed	LAMP: A Database Linking Antimicrobial Peptides
title_sort	lamp: a database linking antimicrobial peptides
description	The frequent emergence of drug-resistant bacteria has created an urgent demand for new antimicrobial agents. Traditional methods of novel antibiotic development are almost obsolete. Antimicrobial peptides (AMPs) are now regarded as a potential solution to revive the traditional methods of antibiotic development, although, until now, many AMPs have failed in clinical trials. A comprehensive database of AMPs with information about their antimicrobial activity and cytotoxicity will help promote the process of finding novel AMPs with improved antimicrobial activity and reduced cytotoxicity and eventually accelerate the speed of translating the discovery of new AMPs into clinical or preclinical trials. LAMP, a database linking AMPs, serves as a tool to aid the discovery and design of AMPs as new antimicrobial agents. The current version of LAMP has 5,547 entries, comprising 3,904 natural AMPs and 1,643 synthetic peptides. The database can be queried using either simply keywords or combinatorial conditions searches. Equipped with the detailed antimicrobial activity and cytotoxicity data, the cross-linking and top similar AMPs functions implemented in LAMP will help enhance our current understanding of AMPs and this may speed up the development of new AMPs for medical applications. LAMP is freely available at: http://biotechlab.fudan.edu.cn/database/lamp.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688957/
_version_	1611988452047323136

LAMP: A Database Linking Antimicrobial Peptides

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