Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar by a Specific Anopheles Salivary Biomarker

Standard entomological methods for evaluating the impact of vector control lack sensitivity in low-malaria-risk areas. The detection of human IgG specific to Anopheles gSG6-P1 salivary antigen reflects a direct measure of human–vector contact. This study aimed to assess the effectiveness of a range...

Full description

Bibliographic Details
Main Authors:	Drame, Papa Makhtar, Diallo, Abdoulaye, Poinsignon, Anne, Boussari, Olayide, Dos Santos, Stephanie, Machault, Vanessa, Lalou, Richard, Cornelie, Sylvie, LeHesran, Jean-Yves, Remoue, Franck
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688790/

id	pubmed-3688790
recordtype	oai_dc
spelling	pubmed-36887902013-07-09 Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar by a Specific Anopheles Salivary Biomarker Drame, Papa Makhtar Diallo, Abdoulaye Poinsignon, Anne Boussari, Olayide Dos Santos, Stephanie Machault, Vanessa Lalou, Richard Cornelie, Sylvie LeHesran, Jean-Yves Remoue, Franck Research Article Standard entomological methods for evaluating the impact of vector control lack sensitivity in low-malaria-risk areas. The detection of human IgG specific to Anopheles gSG6-P1 salivary antigen reflects a direct measure of human–vector contact. This study aimed to assess the effectiveness of a range of vector control measures (VCMs) in urban settings by using this biomarker approach. The study was conducted from October to December 2008 on 2,774 residents of 45 districts of urban Dakar. IgG responses to gSG6-P1 and the use of malaria VCMs highly varied between districts. At the district level, specific IgG levels significantly increased with age and decreased with season and with VCM use. The use of insecticide-treated nets, by drastically reducing specific IgG levels, was by far the most efficient VCM regardless of age, season or exposure level to mosquito bites. The use of spray bombs was also associated with a significant reduction of specific IgG levels, whereas the use of mosquito coils or electric fans/air conditioning did not show a significant effect. Human IgG response to gSG6-P1 as biomarker of vector exposure represents a reliable alternative for accurately assessing the effectiveness of malaria VCM in low-malaria-risk areas. This biomarker tool could be especially relevant for malaria control monitoring and surveillance programmes in low-exposure/low-transmission settings. Public Library of Science 2013-06-20 /pmc/articles/PMC3688790/ /pubmed/23840448 http://dx.doi.org/10.1371/journal.pone.0066354 Text en © 2013 Drame et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Drame, Papa Makhtar Diallo, Abdoulaye Poinsignon, Anne Boussari, Olayide Dos Santos, Stephanie Machault, Vanessa Lalou, Richard Cornelie, Sylvie LeHesran, Jean-Yves Remoue, Franck
spellingShingle	Drame, Papa Makhtar Diallo, Abdoulaye Poinsignon, Anne Boussari, Olayide Dos Santos, Stephanie Machault, Vanessa Lalou, Richard Cornelie, Sylvie LeHesran, Jean-Yves Remoue, Franck Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar by a Specific Anopheles Salivary Biomarker
author_facet	Drame, Papa Makhtar Diallo, Abdoulaye Poinsignon, Anne Boussari, Olayide Dos Santos, Stephanie Machault, Vanessa Lalou, Richard Cornelie, Sylvie LeHesran, Jean-Yves Remoue, Franck
author_sort	Drame, Papa Makhtar
title	Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar by a Specific Anopheles Salivary Biomarker
title_short	Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar by a Specific Anopheles Salivary Biomarker
title_full	Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar by a Specific Anopheles Salivary Biomarker
title_fullStr	Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar by a Specific Anopheles Salivary Biomarker
title_full_unstemmed	Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar by a Specific Anopheles Salivary Biomarker
title_sort	evaluation of the effectiveness of malaria vector control measures in urban settings of dakar by a specific anopheles salivary biomarker
description	Standard entomological methods for evaluating the impact of vector control lack sensitivity in low-malaria-risk areas. The detection of human IgG specific to Anopheles gSG6-P1 salivary antigen reflects a direct measure of human–vector contact. This study aimed to assess the effectiveness of a range of vector control measures (VCMs) in urban settings by using this biomarker approach. The study was conducted from October to December 2008 on 2,774 residents of 45 districts of urban Dakar. IgG responses to gSG6-P1 and the use of malaria VCMs highly varied between districts. At the district level, specific IgG levels significantly increased with age and decreased with season and with VCM use. The use of insecticide-treated nets, by drastically reducing specific IgG levels, was by far the most efficient VCM regardless of age, season or exposure level to mosquito bites. The use of spray bombs was also associated with a significant reduction of specific IgG levels, whereas the use of mosquito coils or electric fans/air conditioning did not show a significant effect. Human IgG response to gSG6-P1 as biomarker of vector exposure represents a reliable alternative for accurately assessing the effectiveness of malaria VCM in low-malaria-risk areas. This biomarker tool could be especially relevant for malaria control monitoring and surveillance programmes in low-exposure/low-transmission settings.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688790/
_version_	1611988363048386560

Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar by a Specific Anopheles Salivary Biomarker

Similar Items