A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease

A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease

Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 e...

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Bibliographic Details
Main Authors: Al-Hassi, H O, Bernardo, D, Murugananthan, A U, Mann, E R, English, N R, Jones, A, Kamm, M A, Arebi, N, Hart, A L, Blakemore, A I F, Stagg, A J, Knight, S C
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684777/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684777/

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