Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination

Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination

Demyelination is one of the pathological hallmarks of multiple sclerosis (MS). To date, no therapy is available which directly potentiates endogenous remyelination. Interleukin-11 (IL-11), a member of the gp130 family of cytokines, is upregulated in MS lesions. Systemic IL-11 treatment was shown to...

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Bibliographic Details
Main Authors: Maheshwari, Anurag, Janssens, Kris, Bogie, Jeroen, Van Den Haute, Chris, Struys, Tom, Lambrichts, Ivo, Baekelandt, Veerle, Stinissen, Piet, Hendriks, Jerome J. A., Slaets, Helena, Hellings, Niels
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683504/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683504/

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