The Role of microRNA in Gastric Malignancy
Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastro-duodenal ulcer, and gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Many miRNA genes are expressed in a tissue-specific manner and play importa...
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| Format: | Online |
| Language: | English |
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Molecular Diversity Preservation International (MDPI)
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676795/ |
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pubmed-36767952013-07-02 The Role of microRNA in Gastric Malignancy Nishizawa, Toshihiro Suzuki, Hidekazu Review Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastro-duodenal ulcer, and gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Many miRNA genes are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Recent discoveries have shed new light on the involvement of miRNAs in gastric malignancy. However, at the same time, several miRNAs have been associated with opposing events, leading to reduced inflammation, inhibition of malignancy, and increased apoptosis of transformed cells. The regulation of miRNA expression could be a novel strategy in the chemoprevention of human gastric malignancy. In this article, the biological importance of miRNAs in gastric malignancy is summarized. Molecular Diversity Preservation International (MDPI) 2013-04-29 /pmc/articles/PMC3676795/ /pubmed/23629677 http://dx.doi.org/10.3390/ijms14059487 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Nishizawa, Toshihiro Suzuki, Hidekazu |
| spellingShingle |
Nishizawa, Toshihiro Suzuki, Hidekazu The Role of microRNA in Gastric Malignancy |
| author_facet |
Nishizawa, Toshihiro Suzuki, Hidekazu |
| author_sort |
Nishizawa, Toshihiro |
| title |
The Role of microRNA in Gastric Malignancy |
| title_short |
The Role of microRNA in Gastric Malignancy |
| title_full |
The Role of microRNA in Gastric Malignancy |
| title_fullStr |
The Role of microRNA in Gastric Malignancy |
| title_full_unstemmed |
The Role of microRNA in Gastric Malignancy |
| title_sort |
role of microrna in gastric malignancy |
| description |
Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastro-duodenal ulcer, and gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Many miRNA genes are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Recent discoveries have shed new light on the involvement of miRNAs in gastric malignancy. However, at the same time, several miRNAs have been associated with opposing events, leading to reduced inflammation, inhibition of malignancy, and increased apoptosis of transformed cells. The regulation of miRNA expression could be a novel strategy in the chemoprevention of human gastric malignancy. In this article, the biological importance of miRNAs in gastric malignancy is summarized. |
| publisher |
Molecular Diversity Preservation International (MDPI) |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676795/ |
| _version_ |
1611984804539006976 |