Small Molecule R1498 as a Well-Tolerated and Orally Active Kinase Inhibitor for Hepatocellular Carcinoma and Gastric Cancer Treatment via Targeting Angiogenesis and Mitosis Pathways

Small Molecule R1498 as a Well-Tolerated and Orally Active Kinase Inhibitor for Hepatocellular Carcinoma and Gastric Cancer Treatment via Targeting Angiogenesis and Mitosis Pathways

Protein kinases play important roles in tumor development and progression. Lots of kinase inhibitors have entered into market and show promising clinical benefits. Here we report the discovery of a novel small molecule, well-tolerated, orally active kinase inhibitor, R1498, majorly targeting both an...

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Bibliographic Details
Main Authors: Zhang, Chao, Wu, Xihan, Zhang, Meifang, Zhu, Liangcheng, Zhao, Rong, Xu, Danqing, Lin, Zhaohu, Liang, Chungen, Chen, Taiping, Chen, Li, Ren, Yi, Zhang, Joe, Qin, Ning, Zhang, Xiongwen
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673949/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673949/

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