Fatty Acid Synthase Is a Key Target in Multiple Essential Tumor Functions of Prostate Cancer: Uptake of Radiolabeled Acetate as a Predictor of the Targeted Therapy Outcome

Fatty Acid Synthase Is a Key Target in Multiple Essential Tumor Functions of Prostate Cancer: Uptake of Radiolabeled Acetate as a Predictor of the Targeted Therapy Outcome

Fatty acid synthase (FASN) expression is elevated in several cancers, and this over-expression is associated with poor prognosis. Inhibitors of FASN, such as orlistat, reportedly show antitumor effects against cancers that over-express FASN, making FASN a promising therapeutic target. However, large...

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Bibliographic Details
Main Authors: Yoshii, Yukie, Furukawa, Takako, Oyama, Nobuyuki, Hasegawa, Yoko, Kiyono, Yasushi, Nishii, Ryuichi, Waki, Atsuo, Tsuji, Atsushi B., Sogawa, Chizuru, Wakizaka, Hidekatsu, Fukumura, Toshimitsu, Yoshii, Hiroshi, Fujibayashi, Yasuhisa, Lewis, Jason S., Saga, Tsuneo
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669310/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669310/

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