An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Several types of animal models of human thyroid carcinomas have been established, including subcutaneous xenograft and orthotopic implantation of cancer cells into immunodeficient mice. Subcutaneous xenograft models have been valuable for preclinical screening and evaluation of new therapeutic treat...
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| Format: | Online |
| Language: | English |
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MyJove Corporation
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664970/ |
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pubmed-36649702015-04-17 An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma Sewell, Will Reeb, Ashley Lin, Reigh-Yi Cancer Biology Several types of animal models of human thyroid carcinomas have been established, including subcutaneous xenograft and orthotopic implantation of cancer cells into immunodeficient mice. Subcutaneous xenograft models have been valuable for preclinical screening and evaluation of new therapeutic treatments. There are a number of advantages to using a subcutaneous model; 1) rapid, 2) reproducible, and 3) tumor establishment, growth, and response to therapeutic agents may be monitored by visual inspection. However, substantial evidence has shed light on the short-comings of subcutaneous xenograft models1-3. For instance, medicinal treatments demonstrating curative properties in subcutaneous xenograft models often have no notable impact on the human disease. The microenvironment of the site of xenographic transplantation or injection lies at the heart of this dissimilarity. MyJove Corporation 2013-04-17 /pmc/articles/PMC3664970/ /pubmed/23628990 http://dx.doi.org/10.3791/50097 Text en Copyright © 2013, Journal of Visualized Experiments http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visithttp://creativecommons.org/licenses/by-nc-nd/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sewell, Will Reeb, Ashley Lin, Reigh-Yi |
| spellingShingle |
Sewell, Will Reeb, Ashley Lin, Reigh-Yi An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma |
| author_facet |
Sewell, Will Reeb, Ashley Lin, Reigh-Yi |
| author_sort |
Sewell, Will |
| title |
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma |
| title_short |
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma |
| title_full |
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma |
| title_fullStr |
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma |
| title_full_unstemmed |
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma |
| title_sort |
orthotopic mouse model of anaplastic thyroid carcinoma |
| description |
Several types of animal models of human thyroid carcinomas have been established, including subcutaneous xenograft and orthotopic implantation of cancer cells into immunodeficient mice. Subcutaneous xenograft models have been valuable for preclinical screening and evaluation of new therapeutic treatments. There are a number of advantages to using a subcutaneous model; 1) rapid, 2) reproducible, and 3) tumor establishment, growth, and response to therapeutic agents may be monitored by visual inspection. However, substantial evidence has shed light on the short-comings of subcutaneous xenograft models1-3. For instance, medicinal treatments demonstrating curative properties in subcutaneous xenograft models often have no notable impact on the human disease. The microenvironment of the site of xenographic transplantation or injection lies at the heart of this dissimilarity. |
| publisher |
MyJove Corporation |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664970/ |
| _version_ |
1611981391498575872 |