Reduction of Reactive Oxygen Species Ameliorates Metabolism-Secretion Coupling in Islets of Diabetic GK Rats by Suppressing Lactate Overproduction

Reduction of Reactive Oxygen Species Ameliorates Metabolism-Secretion Coupling in Islets of Diabetic GK Rats by Suppressing Lactate Overproduction

We previously demonstrated that impaired glucose-induced insulin secretion (IS) and ATP elevation in islets of Goto-Kakizaki (GK) rats, a nonobese model of diabetes, were significantly restored by 30–60-min suppression of endogenous reactive oxygen species (ROS) overproduction. In this study, we inv...

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Bibliographic Details
Main Authors: Sasaki, Mayumi, Fujimoto, Shimpei, Sato, Yuichi, Nishi, Yuichi, Mukai, Eri, Yamano, Gen, Sato, Hiroki, Tahara, Yumiko, Ogura, Kasane, Nagashima, Kazuaki, Inagaki, Nobuya
Format: Online
Language:English
Published: American Diabetes Association 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661648/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661648/

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