Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle
The actin cytoskeleton–regulating GTPase Rac1 is required for insulin-stimulated GLUT4 translocation in cultured muscle cells. However, involvement of Rac1 and its downstream signaling in glucose transport in insulin-sensitive and insulin-resistant mature skeletal muscle has not previously been inve...
| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
American Diabetes Association
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661612/ |