Galectin-3 Deficiency Accelerates High-Fat Diet–Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic Islets

Galectin-3 Deficiency Accelerates High-Fat Diet–Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic Islets

Obesity-induced diabetes is associated with low-grade inflammation in adipose tissue and macrophage infiltration of islets. We show that ablation of galectin-3 (Gal-3), a galactoside-binding lectin, accelerates high-fat diet–induced obesity and diabetes. Obese LGALS3−/− mice have increased body weig...

Full description

Bibliographic Details
Main Authors: Pejnovic, Nada N., Pantic, Jelena M., Jovanovic, Ivan P., Radosavljevic, Gordana D., Milovanovic, Marija Z., Nikolic, Ivana G., Zdravkovic, Nemanja S., Djukic, Aleksandar L., Arsenijevic, Nebojsa N., Lukic, Miodrag L.
Format: Online
Language:English
Published: American Diabetes Association 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661611/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661611/

Similar Items