The Influenza Virus Protein PB1-F2 Interacts with IKKβ and Modulates NF-κB Signalling

PB1-F2, a protein encoded by a second open reading frame of the influenza virus RNA segment 2, has emerged as a modulator of lung inflammatory responses but the molecular mechanisms underlying this are only poorly understood. Here we show that PB1-F2 inhibits the activation of NF-κB dependent signal...

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Bibliographic Details
Main Authors: Reis, Ana Luísa, McCauley, John W.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660569/