Oral manifestations of McCune-Albright syndrome

Oral manifestations of McCune-Albright syndrome

McCune- Albright Syndrome (MAS) is a rare fibrosseous lesion, characterized by a classic triad of polyostotic fibrous dysplasia (PFD), café –au-lait macules (CALM) and underlying endocrinopathies. We present the oral findings of an interesting case of MAS with relevant review of literature. A 30-yea...

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Main Authors: Aravinda, Konidena, Ratnakar, Pamula, Srinivas, Kandakurti
Format: Online
Language:English
Published: Medknow Publications & Media Pvt Ltd 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659890/
id pubmed-3659890
recordtype oai_dc
spelling pubmed-36598902013-06-17 Oral manifestations of McCune-Albright syndrome Aravinda, Konidena Ratnakar, Pamula Srinivas, Kandakurti Case Report McCune- Albright Syndrome (MAS) is a rare fibrosseous lesion, characterized by a classic triad of polyostotic fibrous dysplasia (PFD), café –au-lait macules (CALM) and underlying endocrinopathies. We present the oral findings of an interesting case of MAS with relevant review of literature. A 30-year-old male presented to us with swelling of both jaws over a period of two years. Cutaneous examination revealed café - au – lait macule over the back, crossing the midline. Skeletal survey showed expansile, osteolytic, mixed radiolucent- radiopaque lesions in skull and jaw bones. Serum alkaline phosphatase was elevated (388 IU/L), with normal calcium, phosphorus, parathyroid hormone and 25 hydroxy vitamin D levels. Diagnosis of McCune- Albright syndrome was made and he was treated with parenteral bisphosphonates (intravenous Zoledronate 4 mg) and is under follow up for surgical recontouring of the jaws. Early recognition facilitates better treatment and improves prognosis by reducing the morbidity. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3659890/ /pubmed/23776876 http://dx.doi.org/10.4103/2230-8210.107878 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Aravinda, Konidena
Ratnakar, Pamula
Srinivas, Kandakurti
spellingShingle Aravinda, Konidena
Ratnakar, Pamula
Srinivas, Kandakurti
Oral manifestations of McCune-Albright syndrome
author_facet Aravinda, Konidena
Ratnakar, Pamula
Srinivas, Kandakurti
author_sort Aravinda, Konidena
title Oral manifestations of McCune-Albright syndrome
title_short Oral manifestations of McCune-Albright syndrome
title_full Oral manifestations of McCune-Albright syndrome
title_fullStr Oral manifestations of McCune-Albright syndrome
title_full_unstemmed Oral manifestations of McCune-Albright syndrome
title_sort oral manifestations of mccune-albright syndrome
description McCune- Albright Syndrome (MAS) is a rare fibrosseous lesion, characterized by a classic triad of polyostotic fibrous dysplasia (PFD), café –au-lait macules (CALM) and underlying endocrinopathies. We present the oral findings of an interesting case of MAS with relevant review of literature. A 30-year-old male presented to us with swelling of both jaws over a period of two years. Cutaneous examination revealed café - au – lait macule over the back, crossing the midline. Skeletal survey showed expansile, osteolytic, mixed radiolucent- radiopaque lesions in skull and jaw bones. Serum alkaline phosphatase was elevated (388 IU/L), with normal calcium, phosphorus, parathyroid hormone and 25 hydroxy vitamin D levels. Diagnosis of McCune- Albright syndrome was made and he was treated with parenteral bisphosphonates (intravenous Zoledronate 4 mg) and is under follow up for surgical recontouring of the jaws. Early recognition facilitates better treatment and improves prognosis by reducing the morbidity.
publisher Medknow Publications & Media Pvt Ltd
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659890/
_version_ 1611979703621517312

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