Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes

The expression of allergic phenotypes involves complex inter-relationships among several Th2 and Th1 cytokines as well as the regulator cytokine interleukin (IL)-10. These direct or indirect interrelationships may distort the true associations of cytokine responses with these phenotypes. In this stu...

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Main Authors:	Zhang, Guicheng, Hayden, Catherine M., Goldblatt, Jack, Holt, Patrick, Le Souëf, Peter N.
Format:	Online
Language:	English
Published:	International Scholarly Research Network 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658504/

id	pubmed-3658504
recordtype	oai_dc
spelling	pubmed-36585042013-05-30 Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes Zhang, Guicheng Hayden, Catherine M. Goldblatt, Jack Holt, Patrick Le Souëf, Peter N. Research Article The expression of allergic phenotypes involves complex inter-relationships among several Th2 and Th1 cytokines as well as the regulator cytokine interleukin (IL)-10. These direct or indirect interrelationships may distort the true associations of cytokine responses with these phenotypes. In this study, we aimed to clarify the effects of the regulatory cytokine IL-10 and Th1 cytokine interferon-gamma (IFN-γ) on allergic phenotypes after adjusting for the correlations with Th2 cytokines. After adjusting for Th2 cytokines, IL-10 and IFN-γ were protective against atopy. Adjusted levels of IL-10 and IFN-γ stimulated with house-dust mite (HDM) were significantly lower in atopics than non-atopics, for IL-10 adjusting for IL-5 (P = 0.002), IL-13 (P = 0.012), IL-9 (P = 0.016), and IL-4 (P = 0.043), and for IFN-γ adjusting for IL-5 (P = 0.005), IL-13 (P = 0.005), and IL-9 (P = 0.037). IL-10 and IFN-γ levels stimulated with phytohaemagglutinin (PHA) and staphylococcal enterotoxin B (SEB) exhibited a similar pattern. The adjusted levels of IL-10 and IFN-γ stimulated with HDM, PHA or SEB were all significantly negatively correlated with total serum IgE, except for IFN-γ stimulated with SEB. Levels of Th2 cytokines distort the associations of IL-10 and IFN-γ with allergic phenotypes. Removing the covariance with Th2 cytokines, both IL-10 and IFN-γ were protective against atopy. International Scholarly Research Network 2011-12-28 /pmc/articles/PMC3658504/ /pubmed/23724228 http://dx.doi.org/10.5402/2011/405813 Text en Copyright © 2011 Guicheng Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhang, Guicheng Hayden, Catherine M. Goldblatt, Jack Holt, Patrick Le Souëf, Peter N.
spellingShingle	Zhang, Guicheng Hayden, Catherine M. Goldblatt, Jack Holt, Patrick Le Souëf, Peter N. Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes
author_facet	Zhang, Guicheng Hayden, Catherine M. Goldblatt, Jack Holt, Patrick Le Souëf, Peter N.
author_sort	Zhang, Guicheng
title	Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes
title_short	Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes
title_full	Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes
title_fullStr	Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes
title_full_unstemmed	Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes
title_sort	th2 cytokine levels distort the association of il-10 and ifn-γ with allergic phenotypes
description	The expression of allergic phenotypes involves complex inter-relationships among several Th2 and Th1 cytokines as well as the regulator cytokine interleukin (IL)-10. These direct or indirect interrelationships may distort the true associations of cytokine responses with these phenotypes. In this study, we aimed to clarify the effects of the regulatory cytokine IL-10 and Th1 cytokine interferon-gamma (IFN-γ) on allergic phenotypes after adjusting for the correlations with Th2 cytokines. After adjusting for Th2 cytokines, IL-10 and IFN-γ were protective against atopy. Adjusted levels of IL-10 and IFN-γ stimulated with house-dust mite (HDM) were significantly lower in atopics than non-atopics, for IL-10 adjusting for IL-5 (P = 0.002), IL-13 (P = 0.012), IL-9 (P = 0.016), and IL-4 (P = 0.043), and for IFN-γ adjusting for IL-5 (P = 0.005), IL-13 (P = 0.005), and IL-9 (P = 0.037). IL-10 and IFN-γ levels stimulated with phytohaemagglutinin (PHA) and staphylococcal enterotoxin B (SEB) exhibited a similar pattern. The adjusted levels of IL-10 and IFN-γ stimulated with HDM, PHA or SEB were all significantly negatively correlated with total serum IgE, except for IFN-γ stimulated with SEB. Levels of Th2 cytokines distort the associations of IL-10 and IFN-γ with allergic phenotypes. Removing the covariance with Th2 cytokines, both IL-10 and IFN-γ were protective against atopy.
publisher	International Scholarly Research Network
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658504/
_version_	1611979213468860416

Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes

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