Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models

Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radic...

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Main Authors:	Quintans-Júnior, Lucindo, Moreira, José C. F., Pasquali, Matheus A. B., Rabie, Soheyla M. S., Pires, André S., Schröder, Rafael, Rabelo, Thallita K., Santos, João P. A., Lima, Pollyana S. S., Cavalcanti, Sócrates C. H., Araújo, Adriano A. S., Quintans, Jullyana S. S., Gelain, Daniel P.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658412/

id	pubmed-3658412
recordtype	oai_dc
spelling	pubmed-36584122013-05-30 Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models Quintans-Júnior, Lucindo Moreira, José C. F. Pasquali, Matheus A. B. Rabie, Soheyla M. S. Pires, André S. Schröder, Rafael Rabelo, Thallita K. Santos, João P. A. Lima, Pollyana S. S. Cavalcanti, Sócrates C. H. Araújo, Adriano A. S. Quintans, Jullyana S. S. Gelain, Daniel P. Research Article Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate. Hindawi Publishing Corporation 2013-01-14 /pmc/articles/PMC3658412/ /pubmed/23724298 http://dx.doi.org/10.1155/2013/459530 Text en Copyright © 2013 Lucindo Quintans-Júnior et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Quintans-Júnior, Lucindo Moreira, José C. F. Pasquali, Matheus A. B. Rabie, Soheyla M. S. Pires, André S. Schröder, Rafael Rabelo, Thallita K. Santos, João P. A. Lima, Pollyana S. S. Cavalcanti, Sócrates C. H. Araújo, Adriano A. S. Quintans, Jullyana S. S. Gelain, Daniel P.
spellingShingle	Quintans-Júnior, Lucindo Moreira, José C. F. Pasquali, Matheus A. B. Rabie, Soheyla M. S. Pires, André S. Schröder, Rafael Rabelo, Thallita K. Santos, João P. A. Lima, Pollyana S. S. Cavalcanti, Sócrates C. H. Araújo, Adriano A. S. Quintans, Jullyana S. S. Gelain, Daniel P. Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
author_facet	Quintans-Júnior, Lucindo Moreira, José C. F. Pasquali, Matheus A. B. Rabie, Soheyla M. S. Pires, André S. Schröder, Rafael Rabelo, Thallita K. Santos, João P. A. Lima, Pollyana S. S. Cavalcanti, Sócrates C. H. Araújo, Adriano A. S. Quintans, Jullyana S. S. Gelain, Daniel P.
author_sort	Quintans-Júnior, Lucindo
title	Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title_short	Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title_full	Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title_fullStr	Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title_full_unstemmed	Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title_sort	antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models
description	Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658412/
_version_	1611979180947275776

Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models

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