Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding

Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding

Drug-induced transcriptional modules (biclusters) were identified and annotated in three human cell lines and rat liver. These were used to assess conservation across systems and to infer and experimentally validate novel drug effects and gene functions.

Bibliographic Details
Main Authors: Iskar, Murat, Zeller, Georg, Blattmann, Peter, Campillos, Monica, Kuhn, Michael, Kaminska, Katarzyna H, Runz, Heiko, Gavin, Anne-Claude, Pepperkok, Rainer, van Noort, Vera, Bork, Peer
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658274/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658274/

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