Basic and applied uses of genome-scale metabolic network reconstructions of Escherichia coli

The genome-scale model (GEM) of metabolism in the bacterium Escherichia coli K-12 has been in development for over a decade and is now in wide use. GEM-enabled studies of E. coli have been primarily focused on six applications: (1) metabolic engineering, (2) model-driven discovery, (3) prediction of...

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Bibliographic Details
Main Authors: McCloskey, Douglas, Palsson, Bernhard Ø, Feist, Adam M
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658273/