Global remodelling of cellular microenvironment due to loss of collagen VII

Loss of collagen VII causes recessive dystrophic epidermolysis bullosa. Quantitative proteomics analysis of the extracellular matrix and secretome of human fibroblasts derived from pathologically altered skin reveals a global remodelling of the cellular microenvironment.

Bibliographic Details
Main Authors: Küttner, Victoria, Mack, Claudia, Rigbolt, Kristoffer TG, Kern, Johannes S, Schilling, Oliver, Busch, Hauke, Bruckner-Tuderman, Leena, Dengjel, Jörn
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658272/
Description
Summary:Loss of collagen VII causes recessive dystrophic epidermolysis bullosa. Quantitative proteomics analysis of the extracellular matrix and secretome of human fibroblasts derived from pathologically altered skin reveals a global remodelling of the cellular microenvironment.