Exploration of Macro-Micro Biomarkers for Dampness-Heat Syndrome Differentiation in Different Diseases

Increased attention is being paid to traditional Chinese medicine (TCM) as a complementary and alternative medicine to provide an effective approach for personalized diagnosis and clinical treatment. TMC performs treatment based on differentiation of TCM syndrome (ZHENG), which may identify special...

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Main Authors:	Dai, Jianye, Sun, Shujun, Peng, Jinghua, Cao, Huijuan, Zheng, Ningning, Fang, Junwei, Li, Qianhua, Jiang, Jian, Zhang, Yongyu, Hu, Yiyang
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654361/

id	pubmed-3654361
recordtype	oai_dc
spelling	pubmed-36543612013-05-24 Exploration of Macro-Micro Biomarkers for Dampness-Heat Syndrome Differentiation in Different Diseases Dai, Jianye Sun, Shujun Peng, Jinghua Cao, Huijuan Zheng, Ningning Fang, Junwei Li, Qianhua Jiang, Jian Zhang, Yongyu Hu, Yiyang Research Article Increased attention is being paid to traditional Chinese medicine (TCM) as a complementary and alternative medicine to provide an effective approach for personalized diagnosis and clinical treatment. TMC performs treatment based on differentiation of TCM syndrome (ZHENG), which may identify special phenotypes by symptoms and signs of patients even if they are in different diseases. There has, however, been skepticism and criticism because syndrome classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which lacks objectivity and repeatability. In order to transform syndrome classification into mainstream medicine, we introduce a macro-micro approach that combines symptoms, clinical indicators, and metabolites. The present paper explores the macro-micro biomarkers of dampness-heat syndrome in chronic hepatitis B and nonalcoholic fatty liver patients, which could provide the basis for developing a possible population-screening tool for selecting target individuals and creating an evaluation index for personalized treatment. Hindawi Publishing Corporation 2013 2013-04-21 /pmc/articles/PMC3654361/ /pubmed/23710231 http://dx.doi.org/10.1155/2013/706762 Text en Copyright © 2013 Jianye Dai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Dai, Jianye Sun, Shujun Peng, Jinghua Cao, Huijuan Zheng, Ningning Fang, Junwei Li, Qianhua Jiang, Jian Zhang, Yongyu Hu, Yiyang
spellingShingle	Dai, Jianye Sun, Shujun Peng, Jinghua Cao, Huijuan Zheng, Ningning Fang, Junwei Li, Qianhua Jiang, Jian Zhang, Yongyu Hu, Yiyang Exploration of Macro-Micro Biomarkers for Dampness-Heat Syndrome Differentiation in Different Diseases
author_facet	Dai, Jianye Sun, Shujun Peng, Jinghua Cao, Huijuan Zheng, Ningning Fang, Junwei Li, Qianhua Jiang, Jian Zhang, Yongyu Hu, Yiyang
author_sort	Dai, Jianye
title	Exploration of Macro-Micro Biomarkers for Dampness-Heat Syndrome Differentiation in Different Diseases
title_short	Exploration of Macro-Micro Biomarkers for Dampness-Heat Syndrome Differentiation in Different Diseases
title_full	Exploration of Macro-Micro Biomarkers for Dampness-Heat Syndrome Differentiation in Different Diseases
title_fullStr	Exploration of Macro-Micro Biomarkers for Dampness-Heat Syndrome Differentiation in Different Diseases
title_full_unstemmed	Exploration of Macro-Micro Biomarkers for Dampness-Heat Syndrome Differentiation in Different Diseases
title_sort	exploration of macro-micro biomarkers for dampness-heat syndrome differentiation in different diseases
description	Increased attention is being paid to traditional Chinese medicine (TCM) as a complementary and alternative medicine to provide an effective approach for personalized diagnosis and clinical treatment. TMC performs treatment based on differentiation of TCM syndrome (ZHENG), which may identify special phenotypes by symptoms and signs of patients even if they are in different diseases. There has, however, been skepticism and criticism because syndrome classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which lacks objectivity and repeatability. In order to transform syndrome classification into mainstream medicine, we introduce a macro-micro approach that combines symptoms, clinical indicators, and metabolites. The present paper explores the macro-micro biomarkers of dampness-heat syndrome in chronic hepatitis B and nonalcoholic fatty liver patients, which could provide the basis for developing a possible population-screening tool for selecting target individuals and creating an evaluation index for personalized treatment.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654361/
_version_	1611977857071841280

Exploration of Macro-Micro Biomarkers for Dampness-Heat Syndrome Differentiation in Different Diseases

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