Immune Responses to Inhalant Allergens
This overview describes the nature of the immune responses induced by the inhalation of allergens. There is a dichotomy in that B cells have multiple mechanisms that limit the amount of immunoglobulin E (IgE) antibody production, whereas T-cell responses are large even in nonallergic subjects. With...
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World Allergy Organization
2008
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650949/ |
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pubmed-3650949 |
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pubmed-36509492013-07-19 Immune Responses to Inhalant Allergens Thomas, Wayne R Hales, Belinda J Review Article This overview describes the nature of the immune responses induced by the inhalation of allergens. There is a dichotomy in that B cells have multiple mechanisms that limit the amount of immunoglobulin E (IgE) antibody production, whereas T-cell responses are large even in nonallergic subjects. With the possible exception of responses to cat allergen, however, T cells from nonallergic subjects have limited effector function of helping IgG antibody, and in house-dust mite allergy, this declines with age. Regulation by interleukin 10 (IL-10)-producing cells and CD25+ T-regulatory cells has been proposed, but critically, there is limited evidence for this, and many studies show the highest IL-10 production by cells from allergic subjects. Recent studies have shown the importance of nonlymphoid chemokines thymic stromal lymphopoietin and IL-27, so studying responses in situ is critical. Most sources of allergens have 1 or 2 dominant allergens, and for house-dust mite, it has been shown that people have a predictable responsiveness to high-, mid-and poor-IgE-binding proteins regardless of the total size of their response. This allergen hierarchy can be used to design improved allergen preparations and to investigate how antiallergen responses are regulated. World Allergy Organization 2008-06-15 /pmc/articles/PMC3650949/ /pubmed/23282404 http://dx.doi.org/10.1097/WOX.0b013e3181788324 Text en Copyright ©2008 World Allergy Organization; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Thomas, Wayne R Hales, Belinda J |
| spellingShingle |
Thomas, Wayne R Hales, Belinda J Immune Responses to Inhalant Allergens |
| author_facet |
Thomas, Wayne R Hales, Belinda J |
| author_sort |
Thomas, Wayne R |
| title |
Immune Responses to Inhalant Allergens |
| title_short |
Immune Responses to Inhalant Allergens |
| title_full |
Immune Responses to Inhalant Allergens |
| title_fullStr |
Immune Responses to Inhalant Allergens |
| title_full_unstemmed |
Immune Responses to Inhalant Allergens |
| title_sort |
immune responses to inhalant allergens |
| description |
This overview describes the nature of the immune responses induced by the inhalation of allergens. There is a dichotomy in that B cells have multiple mechanisms that limit the amount of immunoglobulin E (IgE) antibody production, whereas T-cell responses are large even in nonallergic subjects. With the possible exception of responses to cat allergen, however, T cells from nonallergic subjects have limited effector function of helping IgG antibody, and in house-dust mite allergy, this declines with age. Regulation by interleukin 10 (IL-10)-producing cells and CD25+ T-regulatory cells has been proposed, but critically, there is limited evidence for this, and many studies show the highest IL-10 production by cells from allergic subjects. Recent studies have shown the importance of nonlymphoid chemokines thymic stromal lymphopoietin and IL-27, so studying responses in situ is critical. Most sources of allergens have 1 or 2 dominant allergens, and for house-dust mite, it has been shown that people have a predictable responsiveness to high-, mid-and poor-IgE-binding proteins regardless of the total size of their response. This allergen hierarchy can be used to design improved allergen preparations and to investigate how antiallergen responses are regulated. |
| publisher |
World Allergy Organization |
| publishDate |
2008 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650949/ |
| _version_ |
1611976904230830080 |