Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation

For tumor therapy with light ions and for experimental aspects in particle radiobiology the relative biological effectiveness (RBE) is an important quantity to describe the increased effectiveness of particle radiation. By establishing and analysing a database of ion and photon cell survival data, s...

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Main Authors:	Friedrich, Thomas, Scholz, Uwe, ElsäSser, Thilo, Durante, Marco, Scholz, Michael
Format:	Online
Language:	English
Published:	Oxford University Press 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650740/

id	pubmed-3650740
recordtype	oai_dc
spelling	pubmed-36507402013-05-13 Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation Friedrich, Thomas Scholz, Uwe ElsäSser, Thilo Durante, Marco Scholz, Michael Physics For tumor therapy with light ions and for experimental aspects in particle radiobiology the relative biological effectiveness (RBE) is an important quantity to describe the increased effectiveness of particle radiation. By establishing and analysing a database of ion and photon cell survival data, some remarkable properties of RBE-related quantities were observed. The database consists of 855 in vitro cell survival experiments after ion and photon irradiation. The experiments comprise curves obtained in different labs, using different ion species, different irradiation modalities, the whole range of accessible energies and linear energy transfers (LETs) and various cell types. Each survival curve has been parameterized using the linear-quadratic (LQ) model. The photon parameters, α and β, appear to be slightly anti-correlated, which might point toward an underlying biological mechanism. The RBE values derived from the survival curves support the known dependence of RBE on LET, on particle species and dose. A positive correlation of RBE with the ratio α/β of the photon LQ parameters is found at low doses, which unexpectedly changes to a negative correlation at high doses. Furthermore, we investigated the course of the β coefficient of the LQ model with increasing LET, finding typically a slight initial increase and a final falloff to zero. The observed fluctuations in RBE values of comparable experiments resemble overall RBE uncertainties, which is of relevance for treatment planning. The database can also be used for extensive testing of RBE models. We thus compare simulations with the local effect model to achieve this goal. Oxford University Press 2013-05 2012-12-23 /pmc/articles/PMC3650740/ /pubmed/23266948 http://dx.doi.org/10.1093/jrr/rrs114 Text en © The Author 2012. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Friedrich, Thomas Scholz, Uwe ElsäSser, Thilo Durante, Marco Scholz, Michael
spellingShingle	Friedrich, Thomas Scholz, Uwe ElsäSser, Thilo Durante, Marco Scholz, Michael Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation
author_facet	Friedrich, Thomas Scholz, Uwe ElsäSser, Thilo Durante, Marco Scholz, Michael
author_sort	Friedrich, Thomas
title	Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation
title_short	Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation
title_full	Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation
title_fullStr	Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation
title_full_unstemmed	Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation
title_sort	systematic analysis of rbe and related quantities using a database of cell survival experiments with ion beam irradiation
description	For tumor therapy with light ions and for experimental aspects in particle radiobiology the relative biological effectiveness (RBE) is an important quantity to describe the increased effectiveness of particle radiation. By establishing and analysing a database of ion and photon cell survival data, some remarkable properties of RBE-related quantities were observed. The database consists of 855 in vitro cell survival experiments after ion and photon irradiation. The experiments comprise curves obtained in different labs, using different ion species, different irradiation modalities, the whole range of accessible energies and linear energy transfers (LETs) and various cell types. Each survival curve has been parameterized using the linear-quadratic (LQ) model. The photon parameters, α and β, appear to be slightly anti-correlated, which might point toward an underlying biological mechanism. The RBE values derived from the survival curves support the known dependence of RBE on LET, on particle species and dose. A positive correlation of RBE with the ratio α/β of the photon LQ parameters is found at low doses, which unexpectedly changes to a negative correlation at high doses. Furthermore, we investigated the course of the β coefficient of the LQ model with increasing LET, finding typically a slight initial increase and a final falloff to zero. The observed fluctuations in RBE values of comparable experiments resemble overall RBE uncertainties, which is of relevance for treatment planning. The database can also be used for extensive testing of RBE models. We thus compare simulations with the local effect model to achieve this goal.
publisher	Oxford University Press
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650740/
_version_	1611976864107069440

Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation

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