A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase
Telomerase comprises a reverse transcriptase and an internal RNA template that maintains telomeres in many eukaryotes, and it is a well-validated cancer target. However, there is a dearth of small molecules with efficacy against human telomerase in vivo. We developed a surrogate yeast high-throughpu...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650558/ |