Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis

Steady-state mRNA levels are tightly regulated through a combination of transcriptional and post-transcriptional control mechanisms. The discovery of cis-acting DNA elements that encode these control mechanisms is of high importance. We have investigated the influence of conserved non-coding sequenc...

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Main Authors:	Spangler, Jacob B., Feltus, Frank Alex
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650315/

id	pubmed-3650315
recordtype	oai_dc
spelling	pubmed-36503152013-05-14 Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis Spangler, Jacob B. Feltus, Frank Alex Plant Science Steady-state mRNA levels are tightly regulated through a combination of transcriptional and post-transcriptional control mechanisms. The discovery of cis-acting DNA elements that encode these control mechanisms is of high importance. We have investigated the influence of conserved non-coding sequences (CNSs), DNA patterns retained after an ancient whole genome duplication event, on the breadth of gene expression and the rates of mRNA decay in Arabidopsis thaliana. The absence of CNSs near α duplicate genes was associated with a decrease in breadth of gene expression and slower mRNA decay rates while the presence CNSs near α duplicates was associated with an increase in breadth of gene expression and faster mRNA decay rates. The observed difference in mRNA decay rate was fastest in genes with CNSs in both non-transcribed and transcribed regions, albeit through an unknown mechanism. This study supports the notion that some Arabidopsis CNSs regulate the steady-state mRNA levels through post-transcriptional control mechanisms and that CNSs also play a role in controlling the breadth of gene expression. Frontiers Media S.A. 2013-05-10 /pmc/articles/PMC3650315/ /pubmed/23675377 http://dx.doi.org/10.3389/fpls.2013.00129 Text en Copyright © 2013 Spangler and Feltus. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Spangler, Jacob B. Feltus, Frank Alex
spellingShingle	Spangler, Jacob B. Feltus, Frank Alex Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis
author_facet	Spangler, Jacob B. Feltus, Frank Alex
author_sort	Spangler, Jacob B.
title	Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis
title_short	Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis
title_full	Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis
title_fullStr	Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis
title_full_unstemmed	Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis
title_sort	conserved non-coding sequences are associated with rates of mrna decay in arabidopsis
description	Steady-state mRNA levels are tightly regulated through a combination of transcriptional and post-transcriptional control mechanisms. The discovery of cis-acting DNA elements that encode these control mechanisms is of high importance. We have investigated the influence of conserved non-coding sequences (CNSs), DNA patterns retained after an ancient whole genome duplication event, on the breadth of gene expression and the rates of mRNA decay in Arabidopsis thaliana. The absence of CNSs near α duplicate genes was associated with a decrease in breadth of gene expression and slower mRNA decay rates while the presence CNSs near α duplicates was associated with an increase in breadth of gene expression and faster mRNA decay rates. The observed difference in mRNA decay rate was fastest in genes with CNSs in both non-transcribed and transcribed regions, albeit through an unknown mechanism. This study supports the notion that some Arabidopsis CNSs regulate the steady-state mRNA levels through post-transcriptional control mechanisms and that CNSs also play a role in controlling the breadth of gene expression.
publisher	Frontiers Media S.A.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650315/
_version_	1611976784742449152

Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis

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