Potential of Immunoglobulin A to Prevent Allergic Asthma
Allergic asthma is characterized by bronchial hyperresponsiveness, a defective barrier function, and eosinophilic lower airway inflammation in response to allergens. The inflammation is dominated by Th2 cells and IgE molecules and supplemented with Th17 cells in severe asthma. In contrast, in health...
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Hindawi Publishing Corporation
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649226/ |
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pubmed-36492262013-05-20 Potential of Immunoglobulin A to Prevent Allergic Asthma Gloudemans, Anouk K. Lambrecht, Bart N. Smits, Hermelijn H. Review Article Allergic asthma is characterized by bronchial hyperresponsiveness, a defective barrier function, and eosinophilic lower airway inflammation in response to allergens. The inflammation is dominated by Th2 cells and IgE molecules and supplemented with Th17 cells in severe asthma. In contrast, in healthy individuals, allergen-specific IgA and IgG4 molecules are found but no IgE, and their T cells fail to proliferate in response to allergens, probably because of the development of regulatory processes that actively suppress responses to allergens. The presence of allergen-specific secretory IgA has drawn little attention so far, although a few epidemiological studies point at a reverse association between IgA levels and the incidence of allergic airway disease. This review highlights the latest literature on the role of mucosal IgA in protection against allergic airway disease, the mechanisms described to induce secretory IgA, and the role of (mucosal) dendritic cells in this process. Finally, we discuss how this information can be used to translate into the development of new therapies for allergic diseases based on, or supplemented with, IgA boosting strategies. Hindawi Publishing Corporation 2013 2013-04-11 /pmc/articles/PMC3649226/ /pubmed/23690823 http://dx.doi.org/10.1155/2013/542091 Text en Copyright © 2013 Anouk K. Gloudemans et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Gloudemans, Anouk K. Lambrecht, Bart N. Smits, Hermelijn H. |
| spellingShingle |
Gloudemans, Anouk K. Lambrecht, Bart N. Smits, Hermelijn H. Potential of Immunoglobulin A to Prevent Allergic Asthma |
| author_facet |
Gloudemans, Anouk K. Lambrecht, Bart N. Smits, Hermelijn H. |
| author_sort |
Gloudemans, Anouk K. |
| title |
Potential of Immunoglobulin A to Prevent Allergic Asthma |
| title_short |
Potential of Immunoglobulin A to Prevent Allergic Asthma |
| title_full |
Potential of Immunoglobulin A to Prevent Allergic Asthma |
| title_fullStr |
Potential of Immunoglobulin A to Prevent Allergic Asthma |
| title_full_unstemmed |
Potential of Immunoglobulin A to Prevent Allergic Asthma |
| title_sort |
potential of immunoglobulin a to prevent allergic asthma |
| description |
Allergic asthma is characterized by bronchial hyperresponsiveness, a defective barrier function, and eosinophilic lower airway inflammation in response to allergens. The inflammation is dominated by Th2 cells and IgE molecules and supplemented with Th17 cells in severe asthma. In contrast, in healthy individuals, allergen-specific IgA and IgG4 molecules are found but no IgE, and their T cells fail to proliferate in response to allergens, probably because of the development of regulatory processes that actively suppress responses to allergens. The presence of allergen-specific secretory IgA has drawn little attention so far, although a few epidemiological studies point at a reverse association between IgA levels and the incidence of allergic airway disease. This review highlights the latest literature on the role of mucosal IgA in protection against allergic airway disease, the mechanisms described to induce secretory IgA, and the role of (mucosal) dendritic cells in this process. Finally, we discuss how this information can be used to translate into the development of new therapies for allergic diseases based on, or supplemented with, IgA boosting strategies. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649226/ |
| _version_ |
1611976404518305792 |