Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination

Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer...

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Main Authors:	Bae, Go Eun, Yoon, Nara, Park, Ha Young, Ha, Sang Yun, Cho, Junhun, Lee, Yunkyung, Kim, Kyoung-Mee, Park, Cheol Keun
Format:	Online
Language:	English
Published:	The Korean Society of Pathologists and The Korean Society for Cytopathology 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647129/

id	pubmed-3647129
recordtype	oai_dc
spelling	pubmed-36471292013-05-10 Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination Bae, Go Eun Yoon, Nara Park, Ha Young Ha, Sang Yun Cho, Junhun Lee, Yunkyung Kim, Kyoung-Mee Park, Cheol Keun Case Study Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia. The Korean Society of Pathologists and The Korean Society for Cytopathology 2013-04 2013-04-24 /pmc/articles/PMC3647129/ /pubmed/23667376 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.2.163 Text en © 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bae, Go Eun Yoon, Nara Park, Ha Young Ha, Sang Yun Cho, Junhun Lee, Yunkyung Kim, Kyoung-Mee Park, Cheol Keun
spellingShingle	Bae, Go Eun Yoon, Nara Park, Ha Young Ha, Sang Yun Cho, Junhun Lee, Yunkyung Kim, Kyoung-Mee Park, Cheol Keun Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
author_facet	Bae, Go Eun Yoon, Nara Park, Ha Young Ha, Sang Yun Cho, Junhun Lee, Yunkyung Kim, Kyoung-Mee Park, Cheol Keun
author_sort	Bae, Go Eun
title	Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
title_short	Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
title_full	Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
title_fullStr	Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
title_full_unstemmed	Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
title_sort	silent colonic malakoplakia in a living-donor kidney transplant recipient diagnosed during annual medical examination
description	Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.
publisher	The Korean Society of Pathologists and The Korean Society for Cytopathology
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647129/
_version_	1611975843541680128

Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination

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