CpG-ODN Attenuates Pathological Cardiac Hypertrophy and Heart Failure by Activation of PI3Kα-Akt Signaling

CpG-ODN Attenuates Pathological Cardiac Hypertrophy and Heart Failure by Activation of PI3Kα-Akt Signaling

Phosphoinositide-3-kinase α (PI3Kα) represents a potential novel drug target for pathological cardiac hypertrophy (PCH) and heart failure. Oligodeoxynucleotides containing CpG motifs (CpG-ODN) are classic agonists of Toll-like receptor 9 (TLR9), which typically activates PI3K-Akt signaling in immune...

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Bibliographic Details
Main Authors: Yang, Liang, Cai, Xiangyu, Liu, Jie, Jia, Zhe, Jiao, Jinjin, Zhang, Jincai, Li, Changlin, Li, Jing, Tang, Xiang D.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640052/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640052/

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