Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling

Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in the SOST gene. Its gene product, Sclerostin, is a key negative regulator of bone formation and might therefore serve as a target for the anabolic treatment of osteoporosis. The exact molecular mechanism by whi...

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Bibliographic Details
Main Authors: van Dinther, Maarten, Zhang, Juan, Weidauer, Stella E., Boschert, Verena, Muth, Eva-Maria, Knappik, Achim, de Gorter, David J. J., van Kasteren, Puck B., Frisch, Christian, Mueller, Thomas D., ten Dijke, Peter
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639248/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639248/

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