Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells
Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterize...
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Korean Diabetes Association
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638231/ |
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pubmed-36382312013-05-02 Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells Han, Ji Woong Sin, Min Young Yoon, Young-sup Review Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN. Korean Diabetes Association 2013-04 2013-04-16 /pmc/articles/PMC3638231/ /pubmed/23641349 http://dx.doi.org/10.4093/dmj.2013.37.2.91 Text en Copyright © 2013 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Han, Ji Woong Sin, Min Young Yoon, Young-sup |
| spellingShingle |
Han, Ji Woong Sin, Min Young Yoon, Young-sup Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| author_facet |
Han, Ji Woong Sin, Min Young Yoon, Young-sup |
| author_sort |
Han, Ji Woong |
| title |
Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_short |
Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_full |
Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_fullStr |
Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_full_unstemmed |
Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_sort |
cell therapy for diabetic neuropathy using adult stem or progenitor cells |
| description |
Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN. |
| publisher |
Korean Diabetes Association |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638231/ |
| _version_ |
1611973311558844416 |