Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD-related gene product, Parkin, acts with pink1 t...

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Bibliographic Details
Main Authors: Esposito, Giovanni, Vos, Melissa, Vilain, Sven, Swerts, Jef, De Sousa Valadas, Jorge, Van Meensel, Stefanie, Schaap, Onno, Verstreken, Patrik
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636082/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636082/

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