The Role of Metallothionein in Oxidative Stress

Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living sys...

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Main Authors:	Ruttkay-Nedecky, Branislav, Nejdl, Lukas, Gumulec, Jaromir, Zitka, Ondrej, Masarik, Michal, Eckschlager, Tomas, Stiborova, Marie, Adam, Vojtech, Kizek, Rene
Format:	Online
Language:	English
Published:	Molecular Diversity Preservation International (MDPI) 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634463/

id	pubmed-3634463
recordtype	oai_dc
spelling	pubmed-36344632013-05-02 The Role of Metallothionein in Oxidative Stress Ruttkay-Nedecky, Branislav Nejdl, Lukas Gumulec, Jaromir Zitka, Ondrej Masarik, Michal Eckschlager, Tomas Stiborova, Marie Adam, Vojtech Kizek, Rene Review Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous reports indicate that MT protects cells from exposure to oxidants and electrophiles, which react readily with sulfhydryl groups. Moreover, MT plays a key role in regulation of zinc levels and distribution in the intracellular space. The connections between zinc, MT and cancer are highlighted. Molecular Diversity Preservation International (MDPI) 2013-03-15 /pmc/articles/PMC3634463/ /pubmed/23502468 http://dx.doi.org/10.3390/ijms14036044 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ruttkay-Nedecky, Branislav Nejdl, Lukas Gumulec, Jaromir Zitka, Ondrej Masarik, Michal Eckschlager, Tomas Stiborova, Marie Adam, Vojtech Kizek, Rene
spellingShingle	Ruttkay-Nedecky, Branislav Nejdl, Lukas Gumulec, Jaromir Zitka, Ondrej Masarik, Michal Eckschlager, Tomas Stiborova, Marie Adam, Vojtech Kizek, Rene The Role of Metallothionein in Oxidative Stress
author_facet	Ruttkay-Nedecky, Branislav Nejdl, Lukas Gumulec, Jaromir Zitka, Ondrej Masarik, Michal Eckschlager, Tomas Stiborova, Marie Adam, Vojtech Kizek, Rene
author_sort	Ruttkay-Nedecky, Branislav
title	The Role of Metallothionein in Oxidative Stress
title_short	The Role of Metallothionein in Oxidative Stress
title_full	The Role of Metallothionein in Oxidative Stress
title_fullStr	The Role of Metallothionein in Oxidative Stress
title_full_unstemmed	The Role of Metallothionein in Oxidative Stress
title_sort	role of metallothionein in oxidative stress
description	Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous reports indicate that MT protects cells from exposure to oxidants and electrophiles, which react readily with sulfhydryl groups. Moreover, MT plays a key role in regulation of zinc levels and distribution in the intracellular space. The connections between zinc, MT and cancer are highlighted.
publisher	Molecular Diversity Preservation International (MDPI)
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634463/
_version_	1611972261752864768

The Role of Metallothionein in Oxidative Stress

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