Role of 18F-FDG PET-CT in head and neck squamous cell carcinoma
The role of PET-CT imaging in head and neck squamous cell carcinoma during pre-treatment staging, radiotherapy planning, treatment response assessment and post-therapy follow-up is reviewed with focus on current evidence, controversial issues and future clinical applications. In staging, the role of...
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| Format: | Online |
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Pacini Editore SpA
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631810/ |
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pubmed-36318102013-04-25 Role of 18F-FDG PET-CT in head and neck squamous cell carcinoma CASTALDI, P. LECCISOTTI, L. BUSSU, F. MICCICHÈ, F. RUFINI, V. Review Article The role of PET-CT imaging in head and neck squamous cell carcinoma during pre-treatment staging, radiotherapy planning, treatment response assessment and post-therapy follow-up is reviewed with focus on current evidence, controversial issues and future clinical applications. In staging, the role of 18F-FDG PET-CT is well recognized for detecting cervical nodal involvement as well as for exclusion of distant metastases and synchronous primary tumours. In the evaluation of treatment response, the high negative predictive value of 18F-FDG PET-CT performed at least 8 weeks from the end of radio-chemotherapy allows prevention of unnecessary diagnostic invasive procedures and neck dissection in many patients, with a significant impact on clinical outcome. On the other hand, in this setting, the low positive predictive value due to possible post-radiation inflammation findings requires special care before making a clinical decision. Controversial data are currently available on the role of PET imaging during the course of radio-chemotherapy. The prognostic role of 18F-FDG PET-CT imaging in head and neck squamous cell carcinoma is recently emerging, in addition to the utility of this technique in evaluation of the tumour volume for planning radiation therapy. Additionally, new PET radiopharmaceuticals could provide considerable information on specific tumour characteristics, thus overcoming the limitations of 18F-FDG. Pacini Editore SpA 2013-02 /pmc/articles/PMC3631810/ /pubmed/23620633 Text en © Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
CASTALDI, P. LECCISOTTI, L. BUSSU, F. MICCICHÈ, F. RUFINI, V. |
| spellingShingle |
CASTALDI, P. LECCISOTTI, L. BUSSU, F. MICCICHÈ, F. RUFINI, V. Role of 18F-FDG PET-CT in head and neck squamous cell carcinoma |
| author_facet |
CASTALDI, P. LECCISOTTI, L. BUSSU, F. MICCICHÈ, F. RUFINI, V. |
| author_sort |
CASTALDI, P. |
| title |
Role of 18F-FDG PET-CT in head and neck squamous
cell carcinoma |
| title_short |
Role of 18F-FDG PET-CT in head and neck squamous
cell carcinoma |
| title_full |
Role of 18F-FDG PET-CT in head and neck squamous
cell carcinoma |
| title_fullStr |
Role of 18F-FDG PET-CT in head and neck squamous
cell carcinoma |
| title_full_unstemmed |
Role of 18F-FDG PET-CT in head and neck squamous
cell carcinoma |
| title_sort |
role of 18f-fdg pet-ct in head and neck squamous
cell carcinoma |
| description |
The role of PET-CT imaging in head and neck squamous cell carcinoma during pre-treatment staging, radiotherapy planning, treatment response assessment and post-therapy follow-up is reviewed with focus on current evidence, controversial issues and future clinical applications. In staging, the role of 18F-FDG PET-CT is well recognized for detecting cervical nodal involvement as well as for exclusion of distant metastases and synchronous primary tumours. In the evaluation of treatment response, the high negative predictive value of 18F-FDG PET-CT performed at least 8 weeks from the end of radio-chemotherapy allows prevention of unnecessary diagnostic invasive procedures and neck dissection in many patients, with a significant impact on clinical outcome. On the other hand, in this setting, the low positive predictive value due to possible post-radiation inflammation findings requires special care before making a clinical decision. Controversial data are currently available on the role of PET imaging during the course of radio-chemotherapy. The prognostic role of 18F-FDG PET-CT imaging in head and neck squamous cell carcinoma is recently emerging, in addition to the utility of this technique in evaluation of the tumour volume for planning radiation therapy. Additionally, new PET radiopharmaceuticals could provide considerable information on specific tumour characteristics, thus overcoming the limitations of 18F-FDG. |
| publisher |
Pacini Editore SpA |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631810/ |
| _version_ |
1611971543035805696 |