Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT activation confers a poor prognosis. However, the fun...

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Bibliographic Details
Main Authors: Radulescu, S, Ridgway, R A, Cordero, J, Athineos, D, Salgueiro, P, Poulsom, R, Neumann, J, Jung, A, Patel, S, Woodgett, J, Barker, N, Pritchard, D M, Oien, K, Sansom, O J
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631308/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631308/

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