Central and Peripheral Retina Arise through Distinct Developmental Paths
In the mature eye, three distinct tissue fates, retina, ciliary body, and iris, arrange with a strict linear organization along the central (back) to peripheral (front) axis. The establishment of this topographical relationship within the optic vesicle is not well understood. We use a targeted vital...
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| Format: | Online |
| Language: | English |
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Public Library of Science
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628928/ |
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pubmed-3628928 |
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pubmed-36289282013-04-23 Central and Peripheral Retina Arise through Distinct Developmental Paths Venters, Sara J. Mikawa, Takashi Hyer, Jeanette Research Article In the mature eye, three distinct tissue fates, retina, ciliary body, and iris, arrange with a strict linear organization along the central (back) to peripheral (front) axis. The establishment of this topographical relationship within the optic vesicle is not well understood. We use a targeted vital labeling strategy to test the derivation of mature eye tissues from the optic vesicle of the chick embryo. Fate mapping uncovers two distinct origins of the neural retina. Contrary to expectations, the central neural retina has a discrete origin within the posterior optic vesicle. The peripheral retina derives from the distal optic vesicle, sharing a common origin with more peripheral tissue fates. This study identifies for the first time two distinct retinal sub-domains, central and peripheral, which arise during embryogenesis. Identification of these discrete retinal compartments provides a framework for understanding functional and disease processes throughout retinal tissue. Public Library of Science 2013-04-16 /pmc/articles/PMC3628928/ /pubmed/23613848 http://dx.doi.org/10.1371/journal.pone.0061422 Text en © 2013 Venters et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Venters, Sara J. Mikawa, Takashi Hyer, Jeanette |
| spellingShingle |
Venters, Sara J. Mikawa, Takashi Hyer, Jeanette Central and Peripheral Retina Arise through Distinct Developmental Paths |
| author_facet |
Venters, Sara J. Mikawa, Takashi Hyer, Jeanette |
| author_sort |
Venters, Sara J. |
| title |
Central and Peripheral Retina Arise through Distinct Developmental Paths |
| title_short |
Central and Peripheral Retina Arise through Distinct Developmental Paths |
| title_full |
Central and Peripheral Retina Arise through Distinct Developmental Paths |
| title_fullStr |
Central and Peripheral Retina Arise through Distinct Developmental Paths |
| title_full_unstemmed |
Central and Peripheral Retina Arise through Distinct Developmental Paths |
| title_sort |
central and peripheral retina arise through distinct developmental paths |
| description |
In the mature eye, three distinct tissue fates, retina, ciliary body, and iris, arrange with a strict linear organization along the central (back) to peripheral (front) axis. The establishment of this topographical relationship within the optic vesicle is not well understood. We use a targeted vital labeling strategy to test the derivation of mature eye tissues from the optic vesicle of the chick embryo. Fate mapping uncovers two distinct origins of the neural retina. Contrary to expectations, the central neural retina has a discrete origin within the posterior optic vesicle. The peripheral retina derives from the distal optic vesicle, sharing a common origin with more peripheral tissue fates. This study identifies for the first time two distinct retinal sub-domains, central and peripheral, which arise during embryogenesis. Identification of these discrete retinal compartments provides a framework for understanding functional and disease processes throughout retinal tissue. |
| publisher |
Public Library of Science |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628928/ |
| _version_ |
1611970791265533952 |