Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism Differentially Predicts Hippocampal Function in Medication-Free Patients with Schizophrenia

Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism Differentially Predicts Hippocampal Function in Medication-Free Patients with Schizophrenia

A Val66Met single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exaggerated basal hippocampal activity in healthy humans. Several clinical genetic association...

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Bibliographic Details
Main Authors: Eisenberg, Daniel Paul, Ianni, Angela M., Wei, Shau-Ming, Kohn, Philip D., Kolachana, Bhaskar, Apud, José, Weinberger, Daniel R., Berman, Karen F.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628926/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628926/

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