The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection

The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection

Vaccination with the pre-erythrocytic malaria vaccine RTS,S induces high levels of antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a biologically-motivated mathematical model of sporozoite infection fitted to data from malaria-naive adults vaccinated with RTS,S and...

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Bibliographic Details
Main Authors: White, Michael T., Bejon, Philip, Olotu, Ally, Griffin, Jamie T., Riley, Eleanor M., Kester, Kent E., Ockenhouse, Christian F., Ghani, Azra C.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628884/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628884/

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