Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier

A 58-year-old man was diagnosed as a hepatitis B virus (HBV) carrier approximately 30 years ago. He was diagnosed with renal cell carcinoma when he was 57 years old. Radical nephrectomy was performed, and everolimus was administered to treat his lung metastasis. After beginning the everolimus, inter...

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Main Authors:	Mizuno, Shinta, Yamagishi, Yoshiyuki, Ebinuma, Hirotoshi, Nakamoto, Nobuhiro, Katahira, Mai, Sasaki, Aya, Sakamoto, Michiie, Suzuki, Hidekazu, Kanai, Takanori, Hibi, Toshifumi
Format:	Online
Language:	English
Published:	Springer Japan 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627850/

id	pubmed-3627850
recordtype	oai_dc
spelling	pubmed-36278502013-04-17 Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier Mizuno, Shinta Yamagishi, Yoshiyuki Ebinuma, Hirotoshi Nakamoto, Nobuhiro Katahira, Mai Sasaki, Aya Sakamoto, Michiie Suzuki, Hidekazu Kanai, Takanori Hibi, Toshifumi Case Report A 58-year-old man was diagnosed as a hepatitis B virus (HBV) carrier approximately 30 years ago. He was diagnosed with renal cell carcinoma when he was 57 years old. Radical nephrectomy was performed, and everolimus was administered to treat his lung metastasis. After beginning the everolimus, intermittent fever, general fatigue, and jaundice developed. He was admitted under a diagnosis of flare (acute exacerbation) of chronic B hepatitis due to HBV reactivation. Despite intensive care, he died of hepatic failure and fungus infection. The autopsy findings were compatible with hepatic failure due to HBV reactivation by everolimus. Antiviral prophylaxis must be taken into consideration before beginning immunosuppressive therapy such as everolimus in HBV carriers. Springer Japan 2013-03-14 2013-04 /pmc/articles/PMC3627850/ /pubmed/23606919 http://dx.doi.org/10.1007/s12328-013-0371-4 Text en © The Author(s) 2013 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Mizuno, Shinta Yamagishi, Yoshiyuki Ebinuma, Hirotoshi Nakamoto, Nobuhiro Katahira, Mai Sasaki, Aya Sakamoto, Michiie Suzuki, Hidekazu Kanai, Takanori Hibi, Toshifumi
spellingShingle	Mizuno, Shinta Yamagishi, Yoshiyuki Ebinuma, Hirotoshi Nakamoto, Nobuhiro Katahira, Mai Sasaki, Aya Sakamoto, Michiie Suzuki, Hidekazu Kanai, Takanori Hibi, Toshifumi Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier
author_facet	Mizuno, Shinta Yamagishi, Yoshiyuki Ebinuma, Hirotoshi Nakamoto, Nobuhiro Katahira, Mai Sasaki, Aya Sakamoto, Michiie Suzuki, Hidekazu Kanai, Takanori Hibi, Toshifumi
author_sort	Mizuno, Shinta
title	Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier
title_short	Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier
title_full	Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier
title_fullStr	Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier
title_full_unstemmed	Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier
title_sort	progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis b virus carrier
description	A 58-year-old man was diagnosed as a hepatitis B virus (HBV) carrier approximately 30 years ago. He was diagnosed with renal cell carcinoma when he was 57 years old. Radical nephrectomy was performed, and everolimus was administered to treat his lung metastasis. After beginning the everolimus, intermittent fever, general fatigue, and jaundice developed. He was admitted under a diagnosis of flare (acute exacerbation) of chronic B hepatitis due to HBV reactivation. Despite intensive care, he died of hepatic failure and fungus infection. The autopsy findings were compatible with hepatic failure due to HBV reactivation by everolimus. Antiviral prophylaxis must be taken into consideration before beginning immunosuppressive therapy such as everolimus in HBV carriers.
publisher	Springer Japan
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627850/
_version_	1611970462830559232

Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier

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