A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta

A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta

Placenta formation during pregnancy requires chorioallantoic branching morphogenesis that involves establishing an amplifying feedback loop between Frizzled5 and Gcm1 to regulate branching initiation and trophoblast differentiation.

Bibliographic Details
Main Authors: Lu, Jinhua, Zhang, Shuang, Nakano, Haruo, Simmons, David G., Wang, Shumin, Kong, Shuangbo, Wang, Qiang, Shen, Lianju, Tu, Zhaowei, Wang, Weixiang, Wang, Bingyan, Wang, Hongmei, Wang, Yanling, van Es, Johan H., Clevers, Hans, Leone, Gustavo, Cross, James C., Wang, Haibin
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627642/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627642/

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