Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome

Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and presents a complex phenotype that arises from abnormal dosage of genes on this chromosome. However, the individual dosage-sensitive genes underlying each phenotype remain largely unknown. To help dissect genotype – phenotype correl...

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Bibliographic Details
Main Authors: Gribble, Susan M., Wiseman, Frances K., Clayton, Stephen, Prigmore, Elena, Langley, Elizabeth, Yang, Fengtang, Maguire, Sean, Fu, Beiyuan, Rajan, Diana, Sheppard, Olivia, Scott, Carol, Hauser, Heidi, Stephens, Philip J., Stebbings, Lucy A., Ng, Bee Ling, Fitzgerald, Tomas, Quail, Michael A., Banerjee, Ruby, Rothkamm, Kai, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Carter, Nigel P.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626651/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626651/

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