The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS

The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS

Polycystic ovary syndrome (PCOS), one of the most common and complex endocrine disorders affecting up to 15 % of reproductive age women, is considered a predominantly hyperandrogenic syndrome according to the Androgen Excess Society. It is generally accepted that androgens determine the characterist...

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Main Author: Baculescu, N
Format: Online
Language:English
Published: Carol Davila University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624640/
id pubmed-3624640
recordtype oai_dc
spelling pubmed-36246402013-05-15 The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS Baculescu, N Review Polycystic ovary syndrome (PCOS), one of the most common and complex endocrine disorders affecting up to 15 % of reproductive age women, is considered a predominantly hyperandrogenic syndrome according to the Androgen Excess Society. It is generally accepted that androgens determine the characteristic features of PCOS; in this context, a hyperactive androgen receptor (AR) at the levels of the GnRH pulse generator in the hypothalamus and at the granulosa cells in the ovary, skeletal muscle or adipocytes senses initially normal testosterone and dihydrotestosterone as biochemical hyperandrogenism and might be a crucial connection between the vicious circles of the PCOS pathogenesis. Carol Davila University Press 2013-03-15 2013-03-25 /pmc/articles/PMC3624640/ /pubmed/23599814 Text en ©Carol Davila University Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Baculescu, N
spellingShingle Baculescu, N
The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS
author_facet Baculescu, N
author_sort Baculescu, N
title The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS
title_short The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS
title_full The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS
title_fullStr The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS
title_full_unstemmed The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS
title_sort role of androgen receptor activity mediated by the cag repeat polymorphism in the pathogenesis of pcos
description Polycystic ovary syndrome (PCOS), one of the most common and complex endocrine disorders affecting up to 15 % of reproductive age women, is considered a predominantly hyperandrogenic syndrome according to the Androgen Excess Society. It is generally accepted that androgens determine the characteristic features of PCOS; in this context, a hyperactive androgen receptor (AR) at the levels of the GnRH pulse generator in the hypothalamus and at the granulosa cells in the ovary, skeletal muscle or adipocytes senses initially normal testosterone and dihydrotestosterone as biochemical hyperandrogenism and might be a crucial connection between the vicious circles of the PCOS pathogenesis.
publisher Carol Davila University Press
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624640/
_version_ 1611969719981572096

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