Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using...

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Main Authors:	Shirley, Lawrence A., Aguilar, Laura K., Aguilar-Cordova, Estuardo, Bloomston, Mark, Walker, Jon P.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623468/

id	pubmed-3623468
recordtype	oai_dc
spelling	pubmed-36234682013-04-19 Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma Shirley, Lawrence A. Aguilar, Laura K. Aguilar-Cordova, Estuardo Bloomston, Mark Walker, Jon P. Methodology Report Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultrasound in order to directly inject both novel and conventional therapies into pancreatic tumors. We detail the rationale behind this strategy and the many benefits it provides. We then describe our technique in detail, including our experience injecting the AdV-tk adenoviral vector to create an in situ vaccine effect. Hindawi Publishing Corporation 2013 2013-03-27 /pmc/articles/PMC3623468/ /pubmed/23606830 http://dx.doi.org/10.1155/2013/207129 Text en Copyright © 2013 Lawrence A. Shirley et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Shirley, Lawrence A. Aguilar, Laura K. Aguilar-Cordova, Estuardo Bloomston, Mark Walker, Jon P.
spellingShingle	Shirley, Lawrence A. Aguilar, Laura K. Aguilar-Cordova, Estuardo Bloomston, Mark Walker, Jon P. Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
author_facet	Shirley, Lawrence A. Aguilar, Laura K. Aguilar-Cordova, Estuardo Bloomston, Mark Walker, Jon P.
author_sort	Shirley, Lawrence A.
title	Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
title_short	Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
title_full	Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
title_fullStr	Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
title_full_unstemmed	Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
title_sort	therapeutic endoscopic ultrasonography: intratumoral injection for pancreatic adenocarcinoma
description	Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultrasound in order to directly inject both novel and conventional therapies into pancreatic tumors. We detail the rationale behind this strategy and the many benefits it provides. We then describe our technique in detail, including our experience injecting the AdV-tk adenoviral vector to create an in situ vaccine effect.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623468/
_version_	1611969449843228672

Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma

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