Oral Huangqi Formulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Objective. To evaluate the efficacy and safety of oral Huangqi formulae for the treatment of stable COPD. Methods. The major databases were searched until September 2010 and supplemented with a manual search. Randomized controlled trials (RCTs) of oral Huangqi formulae that reported on lung functio...
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Hindawi Publishing Corporation
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623121/ |
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pubmed-36231212013-04-19 Oral Huangqi Formulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis Wu, Lei Chen, Yuanbin Xu, Yinji Guo, Xinfeng Li, Xiaoyan Zhang, Anthony Lin May, Brian H. Xue, Charlie Changli Wen, Zehuai Lin, Lin Review Article Objective. To evaluate the efficacy and safety of oral Huangqi formulae for the treatment of stable COPD. Methods. The major databases were searched until September 2010 and supplemented with a manual search. Randomized controlled trials (RCTs) of oral Huangqi formulae that reported on lung function, St. George's Respiratory Questionnaire, symptom improvement and/or frequency of exacerbations were extracted by two reviewers. The Cochrane tool was used for the assessment of risk of bias in the included trials. Data were analyzed with RevMan 5.1.2 software. Results. 25 RCTs (1,661 participants) were included. Compared with conventional therapy (CT) alone, oral Huangqi formulae plus CT increased FEV1, and a similar result was found comparing Huangqi formulae with no treatment. Improvements in SGRQ total score, COPD-related symptoms and reduction of frequency of exacerbations were found in patients receiving Huangqi formulae plus CT compared to those receiving CT alone or CT plus placebo. No serious adverse events were reported. However, there were some methodological inadequacies in the included studies. Conclusions. The benefits of Huangqi formulae for stable COPD were promising, but its efficacy and safety have not been established due to methodological weakness and possible bias in the reported results. Further rigorously designed studies are warranted. Hindawi Publishing Corporation 2013 2013-03-27 /pmc/articles/PMC3623121/ /pubmed/23606889 http://dx.doi.org/10.1155/2013/705315 Text en Copyright © 2013 Lei Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Wu, Lei Chen, Yuanbin Xu, Yinji Guo, Xinfeng Li, Xiaoyan Zhang, Anthony Lin May, Brian H. Xue, Charlie Changli Wen, Zehuai Lin, Lin |
| spellingShingle |
Wu, Lei Chen, Yuanbin Xu, Yinji Guo, Xinfeng Li, Xiaoyan Zhang, Anthony Lin May, Brian H. Xue, Charlie Changli Wen, Zehuai Lin, Lin Oral Huangqi Formulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| author_facet |
Wu, Lei Chen, Yuanbin Xu, Yinji Guo, Xinfeng Li, Xiaoyan Zhang, Anthony Lin May, Brian H. Xue, Charlie Changli Wen, Zehuai Lin, Lin |
| author_sort |
Wu, Lei |
| title |
Oral Huangqi Formulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_short |
Oral Huangqi Formulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_full |
Oral Huangqi Formulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_fullStr |
Oral Huangqi Formulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed |
Oral Huangqi Formulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_sort |
oral huangqi formulae for stable chronic obstructive pulmonary disease: a systematic review and meta-analysis |
| description |
Objective. To evaluate the efficacy and safety of oral Huangqi
formulae for the treatment of stable COPD. Methods. The major
databases were searched until September 2010 and supplemented with
a manual search. Randomized controlled trials (RCTs) of oral
Huangqi formulae that reported on lung function, St. George's
Respiratory Questionnaire, symptom improvement and/or frequency of
exacerbations were extracted by two reviewers. The Cochrane tool
was used for the assessment of risk of bias in the included
trials. Data were analyzed with RevMan 5.1.2 software. Results. 25
RCTs (1,661 participants) were included. Compared with
conventional therapy (CT) alone, oral Huangqi formulae plus CT
increased FEV1, and a similar result was found comparing Huangqi
formulae with no treatment. Improvements in SGRQ total score,
COPD-related symptoms and reduction of frequency of exacerbations
were found in patients receiving Huangqi formulae plus CT compared
to those receiving CT alone or CT plus placebo. No serious adverse
events were reported. However, there were some methodological
inadequacies in the included studies. Conclusions. The benefits of
Huangqi formulae for stable COPD were promising, but its efficacy
and safety have not been established due to methodological
weakness and possible bias in the reported results. Further
rigorously designed studies are warranted. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623121/ |
| _version_ |
1611969429409628160 |