Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder

Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder

The catechol-O-methyltransferase (COMT) enzyme is critical for the catabolic regulation of synaptic dopamine, resulting in altered cortical functioning. The COMT Val158Met polymorphism has been implicated in human mental illness, with Met/Met homozygotes associated with increased susceptibility to p...

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Bibliographic Details
Main Authors: Norrholm, Seth Davin, Jovanovic, Tanja, Smith, Alicia K., Binder, Elisabeth, Klengel, Torsten, Conneely, Karen, Mercer, Kristina B., Davis, Jennifer S., Kerley, Kimberly, Winkler, Jennifer, Gillespie, Charles F., Bradley, Bekh, Ressler, Kerry J.
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622057/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622057/

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