The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents
Childhood epilepsy continues to be intractable in more than 25% of patients diagnosed with epilepsy. The introduction of new anti-epileptic drugs (AEDs) provides more options for treatment of children with epilepsy. We review the safety and tolerability of seven new AEDs (levetiracetam, lamotrigine,...
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| Format: | Online |
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Libertas Academica
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619554/ |
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pubmed-3619554 |
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pubmed-36195542013-05-06 The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents Kayani, Saima Sirsi, Deepa Expert Review Childhood epilepsy continues to be intractable in more than 25% of patients diagnosed with epilepsy. The introduction of new anti-epileptic drugs (AEDs) provides more options for treatment of children with epilepsy. We review the safety and tolerability of seven new AEDs (levetiracetam, lamotrigine, oxcarbazepine, rufinamide, topiramate, vigabatrin and zonisamide) focusing on their side effect profiles and safety in children and adolescents. Many considerations that are specific for children such as the impact of AEDs on the developing brain are not addressed during the development of new AEDs. They are usually approved as adjunctive therapies based upon clinical trials involving adult patients with partial epilepsy. However, 2 of the AEDs reviewed here (rufinamide and vigabatrin) have FDA approval in the U.S. for specific Pediatric epilepsy syndromes, which are discussed below. The Pediatrician or Neurologists decision on the use of a new AED is an evolutionary process largely dependent on the patient characteristics, personal/peer experiences and literature about efficacy and safety profiles of these medications. Evidence based guidelines are limited due to a lack of randomized controlled trials involving pediatric patients for many of these new AEDs. Libertas Academica 2012-03-08 /pmc/articles/PMC3619554/ /pubmed/23650467 http://dx.doi.org/10.4137/JCNSD.S5097 Text en © 2012 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kayani, Saima Sirsi, Deepa |
| spellingShingle |
Kayani, Saima Sirsi, Deepa The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents |
| author_facet |
Kayani, Saima Sirsi, Deepa |
| author_sort |
Kayani, Saima |
| title |
The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents |
| title_short |
The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents |
| title_full |
The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents |
| title_fullStr |
The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents |
| title_full_unstemmed |
The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents |
| title_sort |
safety and tolerability of newer antiepileptic drugs in children and adolescents |
| description |
Childhood epilepsy continues to be intractable in more than 25% of patients diagnosed with epilepsy. The introduction of new anti-epileptic drugs (AEDs) provides more options for treatment of children with epilepsy. We review the safety and tolerability of seven new AEDs (levetiracetam, lamotrigine, oxcarbazepine, rufinamide, topiramate, vigabatrin and zonisamide) focusing on their side effect profiles and safety in children and adolescents. Many considerations that are specific for children such as the impact of AEDs on the developing brain are not addressed during the development of new AEDs. They are usually approved as adjunctive therapies based upon clinical trials involving adult patients with partial epilepsy. However, 2 of the AEDs reviewed here (rufinamide and vigabatrin) have FDA approval in the U.S. for specific Pediatric epilepsy syndromes, which are discussed below. The Pediatrician or Neurologists decision on the use of a new AED is an evolutionary process largely dependent on the patient characteristics, personal/peer experiences and literature about efficacy and safety profiles of these medications. Evidence based guidelines are limited due to a lack of randomized controlled trials involving pediatric patients for many of these new AEDs. |
| publisher |
Libertas Academica |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619554/ |
| _version_ |
1611968431942270976 |