Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism

Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism

Neuropathic pain elevates spinal anandamide (AEA) levels in a way further increased when URB597, an inhibitor of AEA hydrolysis by fatty acid amide hydrolase (FAAH), is injected intrathecally. Spinal AEA reduces neuropathic pain by acting at both cannabinoid CB1 receptors and transient receptor pote...

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Bibliographic Details
Main Authors: Starowicz, Katarzyna, Makuch, Wioletta, Korostynski, Michal, Malek, Natalia, Slezak, Michal, Zychowska, Magdalena, Petrosino, Stefania, De Petrocellis, Luciano, Cristino, Luigia, Przewlocka, Barbara, Di Marzo, Vincenzo
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616060/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616060/

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