In Silico, In Vitro, and In Vivo Studies Indicate the Potential Use of Bolaamphiphiles for Therapeutic siRNAs Delivery

In Silico, In Vitro, and In Vivo Studies Indicate the Potential Use of Bolaamphiphiles for Therapeutic siRNAs Delivery

Specific small interfering RNAs (siRNAs) designed to silence different oncogenic pathways can be used for cancer therapy. However, non-modified naked siRNAs have short half-lives in blood serum and encounter difficulties in crossing biological membranes due to their negative charge. These obstacles...

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Bibliographic Details
Main Authors: Kim, Taejin, Afonin, Kirill A., Viard, Mathias, Koyfman, Alexey Y, Sparks, Selene, Heldman, Eliahu, Grinberg, Sarina, Linder, Charles, Blumenthal, Robert P, Shapiro, Bruce A
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615820/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615820/

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