A model of parity-dependent immunity to placental malaria
Plasmodium falciparum placental infection during pregnancy is harmful for both mother and child. Protection from placental infection is parity-dependent, that is, acquired over consecutive pregnancies. However, the infection status of the placenta can only be assessed at delivery. Here, to better un...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Nature Pub. Group
2013
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615483/ |
| id |
pubmed-3615483 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-36154832013-04-03 A model of parity-dependent immunity to placental malaria Walker, Patrick G. T. Griffin, Jamie T. Cairns, Matt Rogerson, Stephen J. van Eijk, Anna M. ter Kuile, Feiko Ghani, Azra C. Article Plasmodium falciparum placental infection during pregnancy is harmful for both mother and child. Protection from placental infection is parity-dependent, that is, acquired over consecutive pregnancies. However, the infection status of the placenta can only be assessed at delivery. Here, to better understand the mechanism underlying this parity-dependence, we fitted a model linking malaria dynamics within the general population to observed placental histology. Our results suggest that immunity resulting in less prolonged infection is a greater determinant of the parity-specific patterns than immunity that prevents placental sequestration. Our results also suggest the time when maternal blood first flows into the placenta is a high-risk period. Therefore, preventative strategies implementable before or early in pregnancy, such as insecticide-treated net usage in women of child-bearing age or any future vaccine, could substantially reduce the number of women who experience placental infection. Nature Pub. Group 2013-03-19 /pmc/articles/PMC3615483/ /pubmed/23511473 http://dx.doi.org/10.1038/ncomms2605 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Walker, Patrick G. T. Griffin, Jamie T. Cairns, Matt Rogerson, Stephen J. van Eijk, Anna M. ter Kuile, Feiko Ghani, Azra C. |
| spellingShingle |
Walker, Patrick G. T. Griffin, Jamie T. Cairns, Matt Rogerson, Stephen J. van Eijk, Anna M. ter Kuile, Feiko Ghani, Azra C. A model of parity-dependent immunity to placental malaria |
| author_facet |
Walker, Patrick G. T. Griffin, Jamie T. Cairns, Matt Rogerson, Stephen J. van Eijk, Anna M. ter Kuile, Feiko Ghani, Azra C. |
| author_sort |
Walker, Patrick G. T. |
| title |
A model of parity-dependent immunity to placental malaria |
| title_short |
A model of parity-dependent immunity to placental malaria |
| title_full |
A model of parity-dependent immunity to placental malaria |
| title_fullStr |
A model of parity-dependent immunity to placental malaria |
| title_full_unstemmed |
A model of parity-dependent immunity to placental malaria |
| title_sort |
model of parity-dependent immunity to placental malaria |
| description |
Plasmodium falciparum placental infection during pregnancy is harmful for both mother and child. Protection from placental infection is parity-dependent, that is, acquired over consecutive pregnancies. However, the infection status of the placenta can only be assessed at delivery. Here, to better understand the mechanism underlying this parity-dependence, we fitted a model linking malaria dynamics within the general population to observed placental histology. Our results suggest that immunity resulting in less prolonged infection is a greater determinant of the parity-specific patterns than immunity that prevents placental sequestration. Our results also suggest the time when maternal blood first flows into the placenta is a high-risk period. Therefore, preventative strategies implementable before or early in pregnancy, such as insecticide-treated net usage in women of child-bearing age or any future vaccine, could substantially reduce the number of women who experience placental infection. |
| publisher |
Nature Pub. Group |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615483/ |
| _version_ |
1611967278813806592 |