Telomeres shorten at equivalent rates in somatic tissues of adults

Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human studies of telomere attrition were predominantly conducted on leukocytes. However, findings in leukocytes cannot be generalized to other tissues. Here we measure telomere length in leukocytes, skeletal musc...

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Main Authors:	Daniali, Lily, Benetos, Athanase, Susser, Ezra, Kark, Jeremy D, Labat, Carlos, Kimura, Masayuki, Desai, Kunji, Granick, Mark, Aviv, Abraham
Format:	Online
Language:	English
Published:	Nature Pub. Group 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615479/

id	pubmed-3615479
recordtype	oai_dc
spelling	pubmed-36154792013-04-03 Telomeres shorten at equivalent rates in somatic tissues of adults Daniali, Lily Benetos, Athanase Susser, Ezra Kark, Jeremy D Labat, Carlos Kimura, Masayuki Desai, Kunji Granick, Mark Aviv, Abraham Article Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human studies of telomere attrition were predominantly conducted on leukocytes. However, findings in leukocytes cannot be generalized to other tissues. Here we measure telomere length in leukocytes, skeletal muscle, skin and subcutaneous fat of 87 adults (aged 19–77 years). Telomeres are longest in muscle and shortest in leukocytes, yet are strongly correlated between tissues. Notably, the rates of telomere shortening are similar in the four tissues. We infer from these findings that differences in telomere length between proliferative (blood and skin) and minimally proliferative tissues (muscle and fat) are established during early life, and that in adulthood, stem cells of the four tissues replicate at a similar rate. Nature Pub. Group 2013-03-19 /pmc/articles/PMC3615479/ /pubmed/23511462 http://dx.doi.org/10.1038/ncomms2602 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Daniali, Lily Benetos, Athanase Susser, Ezra Kark, Jeremy D Labat, Carlos Kimura, Masayuki Desai, Kunji Granick, Mark Aviv, Abraham
spellingShingle	Daniali, Lily Benetos, Athanase Susser, Ezra Kark, Jeremy D Labat, Carlos Kimura, Masayuki Desai, Kunji Granick, Mark Aviv, Abraham Telomeres shorten at equivalent rates in somatic tissues of adults
author_facet	Daniali, Lily Benetos, Athanase Susser, Ezra Kark, Jeremy D Labat, Carlos Kimura, Masayuki Desai, Kunji Granick, Mark Aviv, Abraham
author_sort	Daniali, Lily
title	Telomeres shorten at equivalent rates in somatic tissues of adults
title_short	Telomeres shorten at equivalent rates in somatic tissues of adults
title_full	Telomeres shorten at equivalent rates in somatic tissues of adults
title_fullStr	Telomeres shorten at equivalent rates in somatic tissues of adults
title_full_unstemmed	Telomeres shorten at equivalent rates in somatic tissues of adults
title_sort	telomeres shorten at equivalent rates in somatic tissues of adults
description	Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human studies of telomere attrition were predominantly conducted on leukocytes. However, findings in leukocytes cannot be generalized to other tissues. Here we measure telomere length in leukocytes, skeletal muscle, skin and subcutaneous fat of 87 adults (aged 19–77 years). Telomeres are longest in muscle and shortest in leukocytes, yet are strongly correlated between tissues. Notably, the rates of telomere shortening are similar in the four tissues. We infer from these findings that differences in telomere length between proliferative (blood and skin) and minimally proliferative tissues (muscle and fat) are established during early life, and that in adulthood, stem cells of the four tissues replicate at a similar rate.
publisher	Nature Pub. Group
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615479/
_version_	1611967277224165376

Telomeres shorten at equivalent rates in somatic tissues of adults

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