Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells
In eukaryotes, deubiquitinases (DUBs) remove ubiquitin conjugates from diverse substrates, altering their stabilities, localizations or activities. Here we show that many DUBs of the USP and UCH subfamilies can be reversibly inactivated upon oxidation by reactive oxygen species in vitro and in cells...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Pub. Group
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615374/ |